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OCR: EFFECTS OF GH REPLACEMENT THERAPY ON PROTEIN METABOLISM placebo group treament group n=9 (6=u) months months baseline baseline post treatment post treatment age (years) 44.4 2.9 48.8 lean body mass (kg) 46.2 6 478 54.9 5.1 58.654 fasting insulin (mu/T) 10.2 1.4 174 11.8 3.7 20.3 6.0* IGF-I (nmoll) 15.5 1.4 16.9 2.3 45.9 4.5 steady-state plasma leucine concentration (moll) 133 129 135 leucine Ra (umol/min/kg body weight) 1.44 0.09 0.08 1.40 0.08 0.08* leucine oxidation rate (umol/min/kg body weight) 0.18 0.01 0.0 0.24 0.02 0.18 0.01 nonoxidative leucine Rd (mol/min/kg body. (weight) 1.25 0.08 0.07 1.16 0.07 1.46 0.08 data are mean SEM. Significant difference baseline P<0.02 P<0.01 1241 eucine 18001 umal cifference